Semaglutide
Semaglutide, originally developed as a treatment for type 2 diabetes, has also been studied and approved for use in a higher dose specifically for weight management in individuals who are overweight or have obesity and have certain related health conditions.
Here's how semaglutide works for weight loss:
Appetite Suppression: Semaglutide works by mimicking the action of a hormone called glucagon-like peptide-1 (GLP-1), which helps regulate appetite and food intake. By activating GLP-1 receptors in the brain, semaglutide can help reduce feelings of hunger and increase feelings of fullness, leading to a decrease in food consumption.
Slowing Gastric Emptying: Like in its use for diabetes management, semaglutide also slows down the emptying of the stomach, which can contribute to feelings of fullness and satiety after meals.
Potential Effects on Energy Expenditure: There is some evidence to suggest that GLP-1 receptor agonists like semaglutide may also have beneficial effects on energy expenditure and metabolism, which could contribute to weight loss.
Clinical trials have shown that semaglutide, specifically for weight management, can lead to significant and sustained weight loss in individuals with overweight or obesity. In these trials, participants receiving semaglutide along with lifestyle modifications (such as diet and exercise) experienced greater weight loss compared to those receiving a placebo or other weight loss interventions.
It's important to note that semaglutide for weight loss is intended for individuals with a body mass index (BMI) of 27 kg/m².
As with any medication, semaglutide for weight loss may cause side effects, including nausea, vomiting, diarrhea, and potential rare risks such as pancreatitis or thyroid tumors. Therefore, it should be used under the supervision of a healthcare provider who can monitor its effects and adjust the treatment regimen as needed.
Semaglutide for weight loss is not a standalone solution and is most effective when used as part of a comprehensive weight management plan that includes lifestyle modifications such as a healthy diet and regular physical activity.